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263 College Avenue, Holland, MI 49423-3646
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SEMINAR SPEAKER: Stephanie Cologna, University of Illinois Chicago
TITLE: “Mass spectrometry enabled proteomics and lipidomics reveal distinct biomarker signatures in Niemann-Pick Type C Disease”
ABSTRACT: Mass spectrometry has become a leading technology in the identification and quantification of biomolecules across varying sample types and in health and disease states. Our laboratory studies Niemann-Pick Type C disease, a rare and fatal neurodegenerative disorder that arises from cholesterol storage in endo/lysosomal compartments. Using mass spectrometry, we have performed biomarker studies in cellular and animal models as well as from biofluids from patients. In this talk, I will share our approach to mass spectrometry-based biomarker discovery and validation and how we are utilizing this strategy to identify novel biomarkers and develop new therapeutic targets.
BIO: Stephanie M. Cologna, PhD is an Associate Professor of Chemistry and Associate Vice Chancellor for Research at the University of Illinois Chicago (UIC). She received her B.S. in Chemistry from the University of Arizona followed by doctoral studies at Texas A&M University under the mentorship of David H. Russell. Dr. Cologna carried out post-doctoral training at the Eunice Kennedy Shriver, National Institute of Child Health and Human Development, National Institutes of Health under the mentorship of Dr. Forbes D. Porter, MD, PhD and Dr. Alfred L. Yergey III, PhD. Her independent research program was established in 2015 at UIC and is focused on integrating mass spectrometry-based proteomics and lipidomics along with mass spectrometry imaging to understand neurodegeneration. A significant component of the Cologna laboratory is focused on the fatal, lysosomal storage disorder, Niemann-Pick Type C including identification and validation of disease biomarkers using mass spectrometry technologies.
Dr. Cologna and her research team have been recognized for their work by the Robert J. Cotter New Investigator Award from the US Human Proteome Organization (2022), the UIC Rising Star Junior Research of the Year (2019) and she has received an NSF CAREER Award (2022). Dr. Cologna’s research is funded by the National Institutes of Health, the National Science Foundation, the US Food and Drug Administration and by several private foundations.
As an Associate Vice Chancellor for Research, Dr. Cologna works closely with faculty in STEM and biomedical research areas at UIC to foster collaborative team science, enhance faculty recognition and to expand the research portfolio.
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