Friday, September 27 at 3:00pm
A. Paul Schaap Science Center, 1000
35 East 12th Street, Holland, MI 49423-3605
"Membranes and membrane proteins: what do they look like and how do
they work together" Dr. Linda Columbus, University of Virginia
Abstract: Despite significant progress in the area of membrane protein structure and stability, many questions still remain. One fundamental question is what is the role of the lipid environment in stabilizing membrane protein structure, function, and dynamics. To begin to understand the interactions between proteins and the solvent environment, the physical properties of the environments used to stabilize membrane protein folds need to be understood. The structure, shape, and dynamics of micelles, bicelles, and membranes will be presented and compared. The impact the differences and similarities of these three environments have on membrane protein structure will be explored.
Biography: After completing a chemistry degree at Smith College, Dr. Columbus pursued her graduate work in biochemistry and molecular biology at ULCA and postdoctoral research at the Scripps Institute. Since 2013, she has been on the faculty of the University of Virginia's chemistry department furthering her work on membrane protein biophysics, and teaching in the general chemistry and biochemistry programs. In addition to her research and teaching, Dr. Columbus serves as associate director of UVa's Global Infectious Disease Institute.