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VERSION:2.0
CALSCALE:GREGORIAN
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CATEGORIES:Academics,Natural & Applied Sciences Division,Chemistry and Bioc
 hemistry
DESCRIPTION:BECKMAN SCHOLARS GUEST SPEAKER: Prof. Dylan Domaille\, Colorado
  University of Mines\n TITLE: Explorations at the Interface of Chemistry\, 
 Biology\, and Biomaterials: Rational Design of Systems to Address Energy an
 d Health Challenges ABSTRACT: The chemical sector is the largest consumer o
 f energy in US manufacturing. To move toward more sustainable chemical prod
 uction\, we are designing cascade reactions that combine biocatalysts and o
 rganocatalysts in single-flask processes. I will describe how a simple\, in
 expensive chemical catalyst can redirect flux in microbial systems to an in
 dustrially relevant intermediate instead of its native metabolic product. W
 e can produce industrial chemicals from renewable feedstocks in single-flas
 k processes with good yields (70%+) and titers (>6 g/L) using this methodol
 ogy. The second portion of the presentation will focus on our efforts to de
 tect signaling molecules in biological systems. I will describe a persisten
 t selectivity challenge in the field and demonstrate how fundamental physic
 al organic studies provide insight into solving this challenge. I will clos
 e by highlighting how the lessons learned can be applied to other materials
  design challenges with a final view toward future work and collaborative o
 pportunities. BIO: Dylan earned undergraduate degrees in both chemistry and
  biology at the University of Oregon before pursuing a Ph.D. in the chemica
 l biology program with Chris Chang at the University of California\, Berkel
 ey. Here\, he designed selective fluorescent probes for imaging copper in l
 ive cells. He continued to a post-doctoral position with Jen Cha at CU Boul
 der in the Department of Chemical and Biological Engineering developing nan
 omaterials\, phage-based diagnostics\, and biomaterials. He joined the facu
 lty in the Department of Chemistry at Mines in the Fall of 2017 as an assis
 tant professor\, where his lab focuses on the bottom-up design of biomateri
 als and chemical tools and employs biocompatible chemistry for sustainable 
 chemical production. He was named a Beckman Young Investigator in 2022 and 
 awarded an NSF CAREER in 2023. His group is currently supported by the NSF\
 , the DOD\, the Office of Economic Development and International Trade\, an
 d the Arnold and Mabel Beckman Foundation.
DTEND:20240223T220000Z
DTSTAMP:20260412T164609Z
DTSTART:20240223T210000Z
GEO:42.786861;-86.104963
LOCATION:A. Paul Schaap Science Center\, Auditorium 1000
SEQUENCE:0
SUMMARY:Chemistry + Biochemistry Seminar Series: Prof. Dylan Domaille\, Col
 orado University of Mines
UID:tag:localist.com\,2008:EventInstance_41736004447721
URL:https://calendar.hope.edu/event/chemistry_seminar_series_2444
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