Chemistry Weekly Seminar: Dr. Janet K. Morrow

Friday, September 15 at 4:00pm to 5:00pm

A. Paul Schaap Science Center, Schaap 1000 (auditorium) 35 East 12th Street, Holland, MI 49423-3605

Abstract

The development of chemical probes that switch on or off with changes in biological environment is of interest for many applications in the field of molecular imaging. Molecular imaging is a type of biomedical imaging that reports on fundamental molecular pathways related to disease. For example, probes that register extracellular tumor pH or redox status may be important in the characterization of metastatic tumor aggressiveness. Our laboratory is involved in the synthesis of new chemical probes (contrast agents) for magnetic resonance imaging (MRI) based on transition metal ions including Fe(III), Fe(II), Co(II) and Ni(II) coordination complexes. The paramagnetic transition metal ion complexes prepared in our laboratory modulate the proton signal of water in the MRI experiment. The design of contrast agents that are responsive to pH, temperature or redox potential and their applications for in vivo imaging studies will be presented.

Biography

Janet Morrow is UB Distinguished Professor of Chemistry at the State University of New York at Buffalo. She earned her B.S. from the University of California, Santa Barbara and her Ph.D. from the University of North Carolina – Chapel Hill. She was awarded an NSF Postdoctoral Fellowship to work at the University of Bordeaux. She returned from France to post-doc at the University of California, San Diego before starting her faculty position at the University at Buffalo.

Dr. Morrow is a bioinorganic chemist, synthesizing inorganic complexes for biomedical, sensing, or catalytic applications. Her research areas include magnetic resonance imaging contrast agents, optical sensing of metal ions, and recognition of unusual DNA or RNA structure by metal complexes.

She has won numerous awards and held many leadership positions in the chemical community. She was an Alfred P. Sloan Fellow and was awarded the NSF Special Award for Creativity. She is currently an Associate Editor for Inorganic Chemistry, and she directs the Research Experiences for Undergraduates Site at the University at Buffalo.

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Event Type

Academics, Natural & Applied Sciences Division, Chemistry and Biochemistry

Summary

Professor Janet K. Morrow, University at Buffalo, SUNY
"Smart MRI contrast agents that respond to biological environment"

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